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Church, PhD,2 Nigel Mackman, PhD,1 and Rafal Pawlinski, PhD1. Silvio Antoniak ... Chae CU, Lee RT, Rifai N, Ridker PM. Blood pressure and inflammation ... Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation The PMC website is updating on October 15, 2024. Learn More or Try it out now. As a library, NLM provides access to scientific literature. Inclusion in an NLM database does not imply endorsement of, or agreement with, the contents by NLM or the National Institutes of Health. Cardiology. Author manuscript; available in PMC 2018 Jan 1.Published in final edited form as:Cardiology. 2017; 136(4): 258–268. Published online 2016 Nov 24. doi: 10.1159/000452269 PMCID: PMC5334284NIHMSID: NIHMS824424PMID: 27880950 Protease-activated receptor 1 contributes to angiotensin II-induced cardiovascular remodeling and inflammation Silvio Antoniak, PhD,1,2 Jessica C. Cardenas, PhD,2 Laura J. Buczek,1 Frank C. Church, PhD,2 Nigel Mackman, PhD,1 and Rafal Pawlinski, PhD1 The publisher's final edited version of this article is available free at Cardiology Angiotensin II (Ang II) plays an important role in cardiovascular disease. It also leads to the activation of coagulation. The coagulation protease thrombin induces cellular responses by activating protease activated receptor 1 (PAR-1). We investigated if PAR-1 contributes to Ang II-induced cardiovascular remodeling and inflammation. PAR-1+/+ (WT) and PAR-1−/− mice were infused with Ang II (600 ng/kg/min) for up to 4 weeks. In WT mice, this dose of Ang II did not cause a significant increase in the blood pressure but caused pathological changes in both the aorta and heart. Ang II infusion resulted in vascular remodeling of the aorta demonstrated by a significant increase in medial wall thickening and perivascular fibrosis. Importantly, both parameters were significantly attenuated by PAR-1 deficiency. Furthermore, perivascular fibrosis around coronary vessels was reduced in Ang II-treated PAR-1−/− mice compared to WT mice. In addition, PAR-1 deficiency significantly attenuated the Ang II-induction of inflammatory cytokines and profibrotic genes in the aortas compared to WT mice. Finally, PAR-1 deficiency had no effect on Ang II-induced heart hypertrophy. However the heart function measured by fractional shortening, was less impaired in PAR-1−/− than in WT mice.
Home|Our Attorneys|William M. Reppeto III Professional Associations and Memberships Although a third-generation native of Dallas, Will spent the first 12 years of his career as a sole practitioner in Boerne, Texas. While practicing in the Texas Hill Country, he served as city attorney for the City of Boerne and was a founding member and director of the Kendall County Bar Association. In those days, Will was often appointed as a Mediator or Attorney Ad Litem in difficult cases. He also frequently assisted other lawyers with complex Family Law cases. Throughout his career, Will’s skillful and knowledgeable representation in all facets of family law has earned him the trust and respect of his clients, opposing counsel, and the courts. In recognition of his work, he has been selected to the Texas Super Lawyers list published by Thomson Reuters. Will has been Board Certified in Family Law by the Texas Board of Legal Specialization since 2002, demonstrating his ongoing commitment to excellence in this area of law. Board Certification requires continuing education and involvement in the issues of family law, including marriage, adoption, divorce, custody, support, and ownership of property acquired before and during marriage. Will is also an author and speaker regarding family law issues. After earning a Bachelor’s Degree in political science from The University of Texas in 1988, Will graduated from the Southern Methodist University Dedman School of Law in 1992. He completed a Comparative Study of Anglo-American Jurisprudence at University College in Oxford, England, and a Comparative Study of Anglo-American Governmental & Historical Perspective at St. Mark’s College of the University of London.
Eugenia Repetto is an associate in the London office and a member of the European Leveraged Finance/Capital Markets Group. Eugenia focuses mainly on international capital markets and finance transactions, including high yield bonds, equity capital markets, and cross-border securities offerings across a broad range of sectors and jurisdictions. She advises and represents issuers, sponsors and underwriters. Prior to joining Milbank, Eugenia worked in the Banking & Finance department of Chiomenti in Milan, where she advised Italian and international clients (including corporate groups, banks, and investment funds) in the structuring, negotiation, and implementation of national and cross-border acquisition, real estate and project finance transactions. Banking and Leveraged Finance Corporate Finance and Securities Europe United Kingdom Milbank Advises Note Purchasers in Connection with NYSE-Listed Borr Drilling’s $200M Placement of High Yield Bonds Milbank Advises on Borr Drilling's $1.54B Debut High Yield Bond Offering and Super Senior Revolving Credit Facility Milbank Advises Saipem S.p.A. on Its €500M Debut Equity-linked Bond Issuance Milbank Advises Globalworth on Its Tender Offer Milbank Advises on Italmatch Chemicals S.p.A.’s High Yield Bond Offering and Refinancing Attorney Advertising. Prior results do not guarantee a similar outcome.