Monika Buczek, PhD Retweeted · Certis Oncology Solutions, Inc. ... Its an awesome project too (MreB + lipid domains)!Please RT! Research Assistant/Associate ... Something went wrong, but don’t fret — let’s give it another shot.
A prolyl hydroxylase domain protein (PHD) that acts on HIF-1α is known (Bruick and ... Barstead R, Raines RT, Kimble J. Prolyl 4-hydroxylase is required for ... Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation Crit Rev Biochem Mol Biol. Author manuscript; available in PMC 2011 Apr 1.Published in final edited form as:Crit Rev Biochem Mol Biol. 2010 Apr; 45(2): 106–124. doi: 10.3109/10409231003627991 PMCID: PMC2841224NIHMSID: NIHMS171516PMID: 20199358 Kelly L. Gorresa and Ronald T. Rainesa,b The publisher's final edited version of this article is available at Crit Rev Biochem Mol Biol Posttranslational modifications can cause profound changes in protein function. Typically, these modifications are reversible, and thus provide a biochemical on–off switch. In contrast, proline residues are the substrates for an irreversible reaction that is the most common posttranslational modification in humans. This reaction, which is catalyzed by prolyl 4-hydroxylase (P4H), yields (2S,4R)-4-hydroxyproline (Hyp). The protein substrates for P4Hs are diverse. Likewise, the biological consequences of prolyl hydroxylation vary widely, and include altering protein conformation and protein–protein interactions, and enabling further modification. The best known role for Hyp is in stabilizing the collagen triple helix. Hyp is also found in proteins with collagen-like domains, as well as elastin, conotoxins, and argonaute 2. A prolyl hydroxylase domain protein acts on the hypoxia inducible factor α, which plays a key role in sensing molecular oxygen, and could act on inhibitory κB kinase and RNA polymerase II. P4Hs are not unique to animals, being found in plants and microbes as well. Here, we review the enzymic catalysts of prolyl hydroxylation, along with the chemical and biochemical consequences of this subtle but abundant posttranslational modification.
Weronika Buczek's Tweets. Weronika Buczek Retweeted ... It's essential to recognize the underlying efforts to complete a Ph.D. #AcademicTwitter · @PhDVoice. Something went wrong, but don’t fret — let’s give it another shot.
Dr. Teresa Buczek, PhD, is a specialist in psychology who treats patients in Henrico, VA. You do not have access to www.vitals.com. The site owner may have set restrictions that prevent you from accessing the site. Was this page helpful? Yes No Performance & security by Cloudflare
---