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There were a number of proposals to build a railroad east from Portland and across central New Hampshire to connect with the Northern RR and therefore the ... NH Central Railroad: Over the years during the railroad era, there were a number of proposals to build a railroad east from Portland and across central New Hampshire to connect with the Northern RR and therefore the Vermont railroads. In July of 1868, at the same legislative session that created the Town of Ashland, the legislature incorporated the New Hampshire Central RR, which was the New Hampshire part of one of these schemes, running from the Maine border, through the towns of Ossipee, Tamworth, Sandwich, Moultonborough, and Center Harbor, to Meredith village where it would connect to the BC&M, then through the towns of New Hampton and Bristol to connect to the Northern RR in Danbury. This would have made Meredith a railroad junction town, at the intersection of an east-west railroad and a north-south railroad, which would be a great economic boon for Meredith. This apparently aroused some envy in Ashland and a desire to have Ashland be that junction town. The second Ashland town meeting was called in August of 1868 to consider articles to raise up to 5% of the valuation of the town to survey a different route for the RR “through the valleys of the Pemigewasset River and Squam Lakes” and an article on whether or not to borrow that money. No action was taken on the articles, perhaps because of poor attendance. (Only 24 ballots were cast for the election of the moderator.) But, at the annual March 1869 meeting, it was voted to invest 5 % of the valuation of the town in NH Central RR stocks, provided the line was built through Ashland. A significant investment, $50 per $1000 of evaluation on the tax rate if paid out in a single year, although probably that amount would have been borrowed. But another way to reroute the railroad was also proposed. At the June 1869 session of the legislature, a state representative from Sandwich proposed an act to amend the charter of the NH Central RR by substituting the word Holderness for Moultonborough and Center Harbor and to put in Ashland in place of Meredith. These word changes and the topography of the area would have required a new route on the north side of the Squam Lakes, and then down the Squam River valley through Ashland village to New Hampton and on to Bristol. The bill was given to the House committee on railroads, but they asked that it be postponed until the next session. The March 1870 Ashland town meeting voted to support this proposed bill. The town meeting also chose Jonathan F. Keyes as an agent to lobby the legislature for this change. He and the other supporters of the change were not however successful. In 1870, the house at the urging of the Railroad committee again postponed the bill. In 1871, the bill was again sent to the Railroad committee, but they took no action and it died in committee. The charter was not changed, and the NH Central RR was never built. But the willingness of the voters to make a major financial investment in the railroad change shows the importance of railroads in their minds.
Oct 16, 2006 ... ... and Notices in the NIH Guide for Grants and Contracts: IDeA NETWORKS OF BIOMEDICAL RESEARCH EXCELLENCE (INBRE), amendment NOT-RR-07-002. NCRR. IDeA NETWORKS OF BIOMEDICAL RESEARCH EXCELLENCE (INBRE), amendment On June 17, 2003 and July 22, 2004 , the National Center for Research Resources (NCRR), National Institutes of Health (NIH), announced limited competitions to inform the scientific community of Requests for Applications (RFAs) for the IDeA Networks of Biomedical Research Excellence (INBRE) program. This notice is to inform the scientific community that the NIH is amending one of the overarching objectives of these RFAs. O bjective 4) as stated in this RFA, is to provide outreach activities to students at undergraduate institutions, community colleges and tribal colleges participating in the state's network . This objective is amended to read: 4) provide outreach activities to students at undergraduate institutions, community colleges, tribal colleges and K-12 institutions participating in the state's network . No additional funds will be provided to support this activity. Those grantees who have an interest in expanding outreach activities to K-12 institutions may rebudget funds available in the Outreach Cores of these INBRE Networks to accomplish this activity. Inquiries regarding programmatic issues should be directed to: Institutional Development Award Program Director Weekly TOC for this Announcement NIH Funding Opportunities and Notices NIH... Turning Discovery Into Health®
Jun 27, 2017 ... You can set the hash policy to Layer 3+4, which would load balance based on TCP connection or flow, which is typically plenty of load balancing. You've been blocked by network security. To continue, log in to your Reddit account or use your developer token If you think you've been blocked by mistake, file a ticket below and we'll look into it.
R-R interval-based sleep apnea screening by a recurrent neural network in a large clinical polysomnography dataset ... Clin Neurophysiol. 2022 Jul:139:80-89. doi: ... An official website of the United States government Here's how you know Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation . 2022 Jul:139:80-89. doi: 10.1016/j.clinph.2022.04.012. Epub 2022 Apr 30. R-R interval-based sleep apnea screening by a recurrent neural network in a large clinical polysomnography dataset Ayako Iwasaki 1 , Koichi Fujiwara 2 , Chikao Nakayama 3 , Yukiyoshi Sumi 4 , Manabu Kano 3 , Tetsuharu Nagamoto 3 , Hiroshi Kadotani 5 DOI: 10.1016/j.clinph.2022.04.012 Objective: Easily detecting patients with undiagnosed sleep apnea syndrome (SAS) requires a home-use SAS screening system. In this study, we validate a previously developed SAS screening methodology using a large clinical polysomnography (PSG) dataset (N = 938). Methods: We combined R-R interval (RRI) and long short-term memory (LSTM), a type of recurrent neural networks, and created a model to discriminate respiratory conditions using the training dataset (N = 468). Its performance was validated using the validation dataset (N = 470). Results: Our method screened patients with severe SAS (apnea hypopnea index; AHI ≥ 30) with an area under the curve (AUC) of 0.92, a sensitivity of 0.80, and a specificity of 0.84. In addition, the model screened patients with moderate/severe SAS (AHI ≥ 15) with an AUC of 0.89, a sensitivity of 0.75, and a specificity of 0.87. Conclusions: Our method achieved high screening performance when applied to a large clinical dataset. Significance: Our method can help realize an easy-to-use SAS screening system because RRI data can be easily measured with a wearable heart rate sensor. It has been validated on a large dataset including subjects with various backgrounds and is expected to perform well in real-world clinical practice.