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Jun 19, 2024 ... Photo shared by Claire Brodsky on June 19, 2024 tagging @adidas, @lespecs ... GRACE JOSHUA. Follow. nikkisanzz's profile picture. nikkisanzz. data:application/x-javascript;%20charset=utf-8;base64,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:3
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May 5, 2020 ... ... L. Goudreau, Ariane Park, John Bertoni, Marie H. Saint-Hilaire ... Grace Bwala, Suzanne Reichwein, Claudia Rocha, Karen Williams, Kelli ... An official website of the United States government Here's how you know Access keysNCBI HomepageMyNCBI HomepageMain ContentMain Navigation Randomized Controlled Trial Ann Intern Med . 2020 May 5;172(9):591-598. doi: 10.7326/M19-2534. Epub 2020 Mar 31. Isradipine Versus Placebo in Early Parkinson Disease: A Randomized Trial Parkinson Study Group STEADY-PD III Investigators Background: Studies suggest that dihydropyridine calcium-channel blockers may be associated with reduced risk for Parkinson disease (PD). Objective: To assess the effect of isradipine, a dihydropyridine calcium-channel blocker, on the rate of clinical progression of PD. Design: Multicenter, randomized, parallel-group, double-blind, placebo-controlled trial. (ClinicalTrials.gov: NCT02168842). Setting: 57 Parkinson Study Group sites in North America. Participants: Patients with early-stage PD (duration <3 years) who were not taking dopaminergic medications at enrollment. Intervention: 5 mg of immediate-release isradipine twice daily or placebo for 36 months. Measurements: The primary outcome was change in the Unified Parkinson's Disease Rating Scale (UPDRS) parts I to III score measured in the antiparkinson medication "ON" state between baseline and 36 months. Secondary outcomes included time to initiation and use of antiparkinson medications, time to onset of motor complications, change in nonmotor disability, and quality-of-life measures. Results: 336 patients were randomly assigned (mean age, 62 years [SD, 9]; 68% men; disease duration, 0.9 year [SD, 0.7]; mean UPDRS part I to III score, 23.1 [SD, 8.6]); 95% of patients completed the study. Adjusted least-squares mean changes in total UPDRS score in the antiparkinson medication ON state over 36 months for isradipine and placebo recipients were 2.99 (95% CI, 0.95 to 5.03) points versus 3.26 (CI, 1.25 to 5.26) points, respectively, with a treatment effect of -0.27 (CI, -3.02 to 2.48) point (P = 0.85). Statistical adjustment for antiparkinson medication use did not change the findings. Secondary outcomes showed no effect of isradipine treatment. The most common adverse effects of isradipine were edema and dizziness.